Discipline 03
HVAC & air handling
AHU-wise ducting, supply and return balancing, pressure cascades and area classification.
AHU-wise ducting, supply and return balancing, pressure cascades and area classification that hold cleanliness grades reliably and economically.
- 01Architecture
- 02HVACDucting, terminals, dampers(this discipline)
- 03Electrical
- 04Utilities / Plumbing
- 05Fire Fighting
- 06Cleanrooms
- 07Automation / BMS
- 08Process Equipments
HVAC & contamination control
The heart of a GMP facility.
HVAC holds cleanliness grades, temperature, humidity and pressure, and it is the largest energy load in the plant. We design it to be compliant, stable and economical to run.
| Grade | Typical use | Design approach |
|---|---|---|
| Grade A | Critical zone where sterile product is exposed | Unidirectional airflow (UDAF) over the open product, within a Grade B room |
| Grade B | Background to Grade A, e.g. aseptic filling room | High air-change rates, terminal HEPA filtration, strict gowning |
| Grade C | Less critical sterile steps, e.g. solution prep | Turbulent flow with HEPA supply, positive to Grade D |
| Grade D | Clean support areas and less critical stages | Filtered supply, controlled temperature and humidity |
Area classification
ISO 14644 and EU GMP Annex 1 grades set early and confirmed in basic design.
AHU-wise zoning
Each system serves a coherent group of rooms, simplifying balancing and qualification.
Monitored & controlled
Differential pressure, temperature and humidity tied into the BMS from day one.
Five layers, one facility.
A pharmaceutical facility only works when every system works together. We design each discipline in-house and coordinate them as one, so the facility performs as a whole, not as a set of parts.
- Architecture & GMP layoutSpace planning, cleanroom construction, wall/ceiling/floor systems, doors and pass-throughs, and the flows that keep contamination out.
- Process & equipmentPFDs, fully annotated P&IDs, equipment specification, sizing and layout.
- Clean & black utilitiesPW, WFI, clean steam and gases on the clean side; chilled water, chillers and compressed air on the black side.
- Electrical & automationPower distribution, cable trays, lighting to lux targets, control panels and monitoring.
Let’s design it right.
From the first concept sketch to an issued-for-construction package, Agon designs pharmaceutical facilities that meet the highest international standards. We would welcome the conversation.